Open AccessPolylysine‐modified titania nanotube arrays for local drug delivery
Author(s) -
Zhang Tao,
Liu Yan,
Zhang Fengfen,
Xiao Xiufeng
Publication year - 2018
Publication title -
micro and nano letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.25
H-Index - 31
ISSN - 1750-0443
DOI - 10.1049/mnl.2017.0312
Subject(s) - polylysine , drug delivery , drug , materials science , nanotube , nanotechnology , chemical engineering , chemistry , biophysics , pharmacology , carbon nanotube , organic chemistry , medicine , engineering , biology
A drug delivery system based on ɛ‐polylysine‐modified titania nanotube (ɛ‐PL‐TNTs) arrays was prepared. Polylysine on the nanotubes’ surface can effectively bind with alendronate, a drug for the treatment of osteoporosis, through chemical bond. The bonds are fairly stable in an acid environment and cannot easily break up in a physiological environment. The ɛ‐PL‐TNTs increased the amount of drug loading by 9% in weight. The in vitro release profile of alendronate from ɛ‐PL‐TNTs showed a significant reduced burst release and an extended overall release of more than 15 days.