Open AccessHampered binding to blood serum albumin and antimicrobial activity of ibuprofen immobilised on magnetic nanoparticles Fe 3 O 4
Author(s) -
NowakJary Julia,
Kozioł Jacek Juliusz
Publication year - 2018
Publication title -
micro and nano letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.25
H-Index - 31
ISSN - 1750-0443
DOI - 10.1049/mnl.2017.0123
Subject(s) - ibuprofen , naproxen , chemistry , albumin , antimicrobial , drug , magnetic nanoparticles , plasma protein binding , nanoparticle , combinatorial chemistry , nuclear chemistry , pharmacology , biophysics , biochemistry , organic chemistry , nanotechnology , materials science , medicine , alternative medicine , pathology , biology
Drug distribution in an organism depends largely on the binding degree of drugs with blood serum proteins like albumin. Only free fraction of the drug can induce a therapeutic effect. A different affinity of particular drugs to proteins is also one of the reasons of the occurrence of drug interactions. It was decided to investigate if the immobilisation of some model drugs on ‘magnetic nanoparticles Fe 3 O 4 (MNPs)’ would influence their activity and protect from binding to albumin. It was proposed to attach the drugs such as ibuprofen (IB), acetylsalicylic acid and naproxen to the MNPs coated with ‘(3‐aminopropyl)triethoxysilane’ by electrostatic interaction since carboxyl groups of the drugs can form ionic bonds with amino groups of the silane. The characterisation of morphology of the obtained nanostructures was also carried out. The drug release studies showed very slow diffusion of the drugs from the MNPs surface. It has been demonstrated that IB immobilised on MNPs exhibits high antimicrobial activity even in its low concentration and in the presence of albumin – in contrast to the unattached form of the drug.