Open AccessCalcium deficiency in hydroxyapatite and its drug delivery applications
Author(s) -
Koppala Sivasankar,
Swamiappan Sasikumar,
Gangarajula Yuvaraj,
Xu Lei,
Sadasivuni Kishor Kumar,
Ponnamma Deepalekshmi,
Rajagopalan Vijayaraghavan
Publication year - 2018
Publication title -
micro and nano letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.25
H-Index - 31
ISSN - 1750-0443
DOI - 10.1049/mnl.2016.0675
Subject(s) - calcium , hydroxyapatites , particle size , materials science , drug delivery , calcination , scanning electron microscope , precipitation , nuclear chemistry , powder diffraction , spectroscopy , drug , energy dispersive x ray spectroscopy , fourier transform infrared spectroscopy , chemical engineering , chemistry , nanotechnology , crystallography , organic chemistry , metallurgy , medicine , pharmacology , composite material , physics , quantum mechanics , meteorology , engineering , catalysis
In this work, calcium deficient hydroxyapatites (HAPs) [Ca 10− x (PO 4 ) 6 (OH) 2 ] [where x = 0 − 0.3] were synthesised by precipitation method and calcined samples were characterised by Fourier transformation infrared spectroscopy, powder X‐ray diffraction, scanning electron microscopy and energy‐dispersive X‐ray spectroscopy techniques to check phase purity, calcium deficiency, particle size and shape. The results indicate that the structure of the HAP can tolerate a calcium deficiency up to 0.2. The calcium deficient HAP ( x = 0.1) powder was found to be highly porous with a particle size below 200 nm. This powder was used as a drug delivery carrier for the drug, ciprofloxacin and sustained release of the drug in the phosphate buffer solution was investigated.