Open AccessAmine functionalised hydroxyapatite nanoparticles for anti‐angiogenesis gene therapy of breast cancer
Author(s) -
Xu Hongjie,
Wei Dajun,
Gai Xiaodong,
Jiang Ying
Publication year - 2016
Publication title -
micro and nano letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.25
H-Index - 31
ISSN - 1750-0443
DOI - 10.1049/mnl.2016.0078
Subject(s) - gene delivery , cytotoxicity , transfection , nanoparticle , genetic enhancement , angiogenesis , breast cancer , cancer research , drug delivery , chemistry , materials science , cancer , pharmacology , nanotechnology , medicine , in vitro , gene , biochemistry
A functionalised hydroxyapatite (HAP) nanoparticles based drug delivery system (DDS) [anti‐angiogenesis (ANG)/amine functionalised HAP (NHAP) nanoparticles] composed of HAP nanoparticles and therapeutic ANG plasmid was successfully developed for gene therapy of breast cancer. ANG/NHAP nanoparticles displayed nano‐sized diameter of around 50 nm and effective plasmid condensation ability. Cellular assays on MCF‐7 cells further confirmed high transfection and ANG efficacy as well as low cytotoxicity of ANG/NHAP nanoparticles, which suggested that ANG/NHAP nanoparticles might be a safe and effective DDS for potential breast cancer gene therapy.