Open AccessElectro‐oxidation and simultaneous determination of amlodipine and atorvastatin in commercial tablets using carbon nanotube modified electrode
Author(s) -
Mohammadi Ali,
Moghaddam Abdolmajid Bayandori,
Eilkhanizadeh Kordestan,
Alikhani Elham,
Mozaffari Shahla,
Yavari Tahereh
Publication year - 2013
Publication title -
micro and nano letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.25
H-Index - 31
ISSN - 1750-0443
DOI - 10.1049/mnl.2013.0080
Subject(s) - differential pulse voltammetry , electrode , materials science , detection limit , carbon nanotube , graphite , cyclic voltammetry , amlodipine , analytical chemistry (journal) , atorvastatin , calibration curve , anode , carbon paste electrode , voltammetry , electrochemistry , composite material , chemistry , chromatography , medicine , blood pressure , radiology , endocrinology
Amlodipine besylate and atorvastatin calcium have been determined by the simultaneous voltammetric method at a multi‐walled carbon nanotubes:graphite (MWCNTs:G) paste electrode. In comparison with a glassy carbon electrode, the prepared electrode showed an increase in the peak current because of the high electroactive surface area and excellent electronic conductivity of MWCNTs. The dependence of currents and potentials on pH were investigated for these components at the surface of the MWCNTs:G paste electrode. Differential pulse voltammetry was applied as a sensitive technique for simultaneous determination of the drugs in commercial tablets. By anodic differential pulse voltammetry, the calibration plot was linear in the range of 2.5–100 µg/ml with standard deviation between 2.7–7.1 and 1.8–8.3% for amlodipine and atorvastatin, respectively. The detection limit was 1 µg/ml at the prepared electrode in the buffered solution pH 6.