Open AccessOne‐pot preparation of small lipid‐indocyanine green nanoparticles to induced intracellular oxidative/thermal stress damage for effective colorectal cancer therapy
Author(s) -
Bi Zhibin,
Huang Lei,
Han Ming,
Ma Jun,
Wang Peilong
Publication year - 2021
Publication title -
micro and nano letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.25
H-Index - 31
ISSN - 1750-0443
DOI - 10.1049/mna2.12093
Subject(s) - indocyanine green , biocompatibility , oxidative stress , in vivo , colorectal cancer , nanoparticle , biophysics , in vitro , intracellular , chemistry , materials science , nanotechnology , cancer , medicine , biochemistry , pathology , organic chemistry , biology , microbiology and biotechnology
In the current study, a one‐pot method to prepare small lipid‐indocyanine green (ICG) nanoparticles (L‐ICG NPs) is proposed for the treatment of colorectal cancer. The L‐ICG NPs showed size distribution at around 20 nm with high stability and biocompatibility. In addition, they can respond to light irradiations to exert oxidative/thermal stress damage, which showed effective anticancer benefits in vitro and in vivo using HT‐29 cells as the model.