Open AccessCo(II) coordination polymer: Treatment activity on vulvovaginal candidiasis by inhibiting the growth of the Candida albicans
Author(s) -
Sun Huaqin,
Li Yanxia,
Ding Zhaoxia,
Xu Shucui,
Cui Qiulian
Publication year - 2021
Publication title -
micro and nano letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.25
H-Index - 31
ISSN - 1750-0443
DOI - 10.1049/mna2.12084
Subject(s) - candida albicans , chemistry , dimethylformamide , pyridine , solvent , triphenylamine , benzoic acid , ligand (biochemistry) , yeast , vulvovaginal candidiasis , nuclear chemistry , medicinal chemistry , polymer chemistry , organic chemistry , receptor , biochemistry , microbiology and biotechnology , biology
By the reaction between Co(NO 3 ) 2 ·6H 2 O and 4‐(bis(4‐(pyridin‐4‐yl)phenyl)amino)benzoic acid (Hbpba), a triphenylamine‐functionalized ligand in CH 3 CN and N , N ‐dimethylformamide (DMF) mixed solvent under the solvothermal conditions, a new coordination polymer (CP) containing Co(II) has been successfully prepared, and its chemical formula is [Co(bpba)(NO 3 )] ( 1 ). The colony‐forming unit (CFU) numbers of the Candida albicans after the compound treatment was measured with diluted micro‐plates assay. In addition to this, the inflammatory cytokines released into the vaginal discharge was determined with enzyme linked immunosorbent assay (ELISA) detection kit. Both pyridine and carboxyl groups have the capabilities to provide polar atoms for interacting with the active sites on target protein, however, results from molecular docking showed that only carboxyl group exhibited activity.