Open AccessFlavonolignans‐routed synthesis of selenium nanowires (SeNWs) and their cytotoxicity, cell migration potential against triple negative breast cancer cells
Author(s) -
Kavithaa Krishnamoorthy,
Paulpandi Manickam,
Vadivalagan Chithravel,
Asaikkutti Annamalai,
Sumathi Sundaravadivelu
Publication year - 2021
Publication title -
micro and nano letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.25
H-Index - 31
ISSN - 1750-0443
DOI - 10.1049/mna2.12022
Subject(s) - triple negative breast cancer , viability assay , cytotoxicity , apoptosis , mtt assay , cancer research , cell growth , cancer cell , cytotoxic t cell , cell , chemistry , cell migration , cancer , breast cancer , in vitro , selenium , microbiology and biotechnology , medicine , biology , biochemistry , organic chemistry
Abstract Recent evidences have demonstrated that bio‐macromolecule assisted nanomaterials syntheses have been widely used for cancer treatment. The aim of this study was to investigate the effects and cellular mechanisms of silymarin‐routed synthesis of selenium nanowires (SeNWs) on cytotoxic and cell migration inhibitory potential against triple negative breast cancer (MDA‐MB‐231) cells. Characterizations of SeNWs were detected by XRD, scanning electron microscopy, and Raman spectrum. Cell proliferation and migration of MDA‐MB‐231 cells were evaluated by MTT and wound assays respectively. The study revealed that SeNWs significantly suppressed the cell viability and cell migration potential compared with the control group. Moreover, SeNWs significantly induce the apoptotic induction in triple negative breast cancer cells. Overall, the current findings highlight the potential cancer therapeutic applications of SeNWs in in vitro condition.