Open AccessOccurrence of HIV eradication for preexposure prophylaxis treatment with a deterministic HIV model
Author(s) -
Chang Hyeygjeon,
Moog Claude,
Astolfi Alessandro
Publication year - 2016
Publication title -
iet systems biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.367
H-Index - 50
eISSN - 1751-8857
pISSN - 1751-8849
DOI - 10.1049/iet-syb.2016.0008
Subject(s) - human immunodeficiency virus (hiv) , stage (stratigraphy) , protocol (science) , medicine , antiretroviral therapy , virus , immunology , virology , viral load , intensive care medicine , biology , pathology , alternative medicine , paleontology
The authors examine the human immunodeficiency virus (HIV) eradication in this study using a mathematical model and analyse the occurrence of virus eradication during the early stage of infection. To this end they use a deterministic HIV‐infection model, modify it to describe the pharmacological dynamics of antiretroviral HIV drugs, and consider the clinical experimental results of preexposure prophylaxis HIV treatment. They also use numerical simulation to model the experimental scenario, thereby supporting the clinical results with a model‐based explanation. The study results indicate that the protocol employed in the experiment can eradicate HIV in infected patients at the early stage of the infection.