Open AccessSynthesising gene clock with toggle switch and oscillator
Author(s) -
Lin ChunLiang,
Chen PoKuei,
Cheng YoungYi
Publication year - 2015
Publication title -
iet systems biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.367
H-Index - 50
eISSN - 1751-8857
pISSN - 1751-8849
DOI - 10.1049/iet-syb.2014.0022
Subject(s) - sine wave , clock signal , square wave , generator (circuit theory) , clock generator , synchronous circuit , clock domain crossing , signal generator , signal (programming language) , square (algebra) , control theory (sociology) , topology (electrical circuits) , physics , computer science , mathematics , electronic circuit , quantum mechanics , power (physics) , control (management) , voltage , geometry , artificial intelligence , combinatorics , programming language
The usefulness of a genetic clock lies in its role to stimulate a sequence of logic reactions for sequential biological circuits. A clock signal is a periodic square wave, its amplitude alternates at a steady frequency between fixed minimal and maximal levels. Transition between the minimum and the maximum is instantaneous for an ideal square wave; however, the function is unrealisable in physical bio‐systems. This research develops a new genetic clock generator based on a genetic oscillator, in which, a sine wave generator is adopted as a signal oscillator. It is shown that combination of a genetic oscillator with a toggle switch is able to generate clock signals forming an efficient way to generate a near square wave. In silico study confirms the proposed idea.