Open AccessSystematic study on G‐protein couple receptor prototypes: did they really evolve from prokaryotic genes?
Author(s) -
Zhang Zaichao,
Jin Zhong,
Zhao Yongbing,
Zhang Zhewen,
Li Rujiao,
Xiao Jingfa,
Wu Jiayan
Publication year - 2014
Publication title -
iet systems biology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.367
H-Index - 50
eISSN - 1751-8857
pISSN - 1751-8849
DOI - 10.1049/iet-syb.2013.0037
Subject(s) - g protein coupled receptor , computational biology , periplasmic space , biology , metabotropic receptor , phylogenetic tree , metabotropic glutamate receptor , gene , genetics , receptor , glutamate receptor , escherichia coli
G‐protein couple receptor (GPCR) is one of the most striking examples of signalling proteins and it is only observed in eukaryotes. Based on various GPCR identification methods and classification systems, several evolutionary presumptions of different GPCR families have been reported. However, the prototype of GPCR still limits our knowledge. By investigating its structure and domain variance, the authors propose that GPCR might be evolved from prokaryotic world. The results given by the authors indicate that metabotropic glutamate receptor family would be the ancestor of GPCR. Phylogenetic analysis hints that one of metabotropic glutamate receptor GABA is possibly formed and evolved from the ancient chemical union of bacteriorhodopsin and periplasmic binding protein. The results obtained by the authors also unprecedentedly demonstrate that specific domains and identical structures are shown in each type of GPCR, which provides unique opportunities for future strategies on GPCR orphans’ prediction and classification.