Open AccessProperties of scaffolds based on chitosan and collagen with bioglass 45S5
Author(s) -
Kaczmarek Beata,
Nadolna Kinga,
Owczarek Agata,
Mazur Olha,
Sionkowska Alina,
Łukowicz Krzysztof,
Vishnu Jithin,
Manivasagam Geetha,
Osyczka Anna M.
Publication year - 2020
Publication title -
iet nanobiotechnology
Language(s) - English
Resource type - Journals
ISSN - 1751-875X
DOI - 10.1049/iet-nbt.2020.0045
Subject(s) - tannic acid , chitosan , bioactive glass , materials science , scaffold , chemical engineering , scanning electron microscope , nanoparticle , porosity , chemistry , composite material , biomedical engineering , nanotechnology , organic chemistry , medicine , engineering
Scaffolds based on chitosan (CTS), collagen (Coll) and glycosaminoglycans (GAG) mixtures cross‐linked by tannic acid (TA) with bioglass 45S5 addition were obtained with the use of the freeze‐drying method. The prepared scaffolds were characterised for morphology, mechanical strength and degradation rate. Moreover, cell viability on the obtained scaffolds was measured with and without the presence of ascorbic acid and dexamethasone. The main purpose of the research was to compare the effectiveness of bioglass 45S5 influence on the physicochemical and biological properties of scaffolds. The results demonstrated that the scaffolds based on the blends of biopolymers cross‐linked by TA are stable in an aqueous environment. Scanning electron microscope images allowed the observation of a porous scaffold structure with interconnected pores. The addition of bioglass nanoparticles improved the mechanical properties and decreased the degradation rate of composite materials. The biological properties were improved for 20% tannic acid addition compared to 5%. However, the addition of bioglass 45S5 did not change to cells response significantly.