Open Access5 Fluorouracil‐loaded biosynthesised gold nanoparticles for the in vitro treatment of human pancreatic cancer cell
Author(s) -
Chinnaiyan Senthil Kumar,
Soloman Agnes Mary,
Perumal Ramesh Kannan,
Gopinath Arun,
Balaraman Madhan
Publication year - 2019
Publication title -
iet nanobiotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.366
H-Index - 38
eISSN - 1751-875X
pISSN - 1751-8741
DOI - 10.1049/iet-nbt.2019.0007
Subject(s) - colloidal gold , zeta potential , nuclear chemistry , mtt assay , selected area diffraction , nanoparticle , chemistry , in vitro , cytotoxicity , fluorouracil , pancreatic cancer , high resolution transmission electron microscopy , nanotechnology , materials science , cancer , biochemistry , transmission electron microscopy , medicine
In this study, green synthesis of gold nanoparticles (AuNPs) was performed by a sunlight irradiation method using the Borassus flabellifer fruit extract as a reducing agent. 5‐Fluorouracil (5‐FU)‐loaded GG capped AuNPs (5FU‐G‐AuNPs) was prepared. The nanoparticles was further characterised by UV‐visible spectra, particle size analysis, zeta potential, SAED, HRTEM, and XRD. The MTT assay results showed the suitability 5‐FU‐G‐AuNPs. In this study, 5‐FU‐G‐AuNPs exhibited potential cytotoxic and apoptotic effects on (MiaPaCa‐2) cell line.