Open AccessSustained delivery of olanzapine from sunflower oil‐based polyol‐urethane nanoparticles synthesised through a cyclic carbonate ring‐opening reaction
Author(s) -
Babanejad Niloofar,
Nabid Mohammad Reza,
Farhadian Abdolreza,
Dorkoosh Farid,
Zarrintaj Payam,
Saeb Mohammad Reza,
Mozafari Masoud
Publication year - 2019
Publication title -
iet nanobiotechnology
Language(s) - English
Resource type - Journals
ISSN - 1751-875X
DOI - 10.1049/iet-nbt.2018.5440
Subject(s) - bioavailability , olanzapine , drug delivery , pharmacokinetics , nanoparticle , polyol , chemistry , pharmacology , nanomedicine , materials science , nanotechnology , organic chemistry , medicine , schizophrenia (object oriented programming) , psychiatry , polyurethane
The forefront horizon of biomedical investigations in recent decades is parcelling‐up and delivery of drugs to achieve controlled/targeted release. In this regard, developing green‐based delivery systems for a spatiotemporal controlling therapeutic agent have drawn a lot of attention. A facile route based on cyclic carbonate ring‐opening reaction has been utilised to synthesise a bio‐based polyol‐containing urethane bond [polyol‐urethane (POU)] as a nanoparticulate drug delivery system of olanzapine in order to enhance its bioavailability. After characterisation, the nanoparticles were also estimated for in vitro release, toxicity, and pharmacokinetic studies. As olanzapine has shown poor bioavailability and permeability in the brain, the sustained release of olanzapine from the designed carriers could enhance pharmacokinetic effectiveness. POU in the aqueous solution formed micelles with a hydrophobic core and embedded olanzapine under the influence of its hydrophobic nature. Drug release from the nanoparticles (90 ± 0.43 nm in diameter) indicated a specific pattern with initial burst release, and then a sustained release behaviour (82 ± 3% after 168 h), by the Higuchi‐based release mechanism. Pharmacokinetics assessments of POU‐olanzapine nanoparticles were carried in male Wistar rats through intravenous administration. The obtained results paved a way to introduce the POU as an efficient platform to enhance the bioavailability of olanzapine in therapeutic methods.