Open AccessControlling fibroblast adhesion and proliferation by 1D Al 2 O 3 nanostructures
Author(s) -
Aktas Oral Cenk,
Metzger Wolfgang,
Mees Lisa,
Martinez Marina Miro,
Haidar Ayman,
Oberringer Martin,
Wennemuth Gunther,
Pütz Norbert,
Ghori Muhammad Zubair,
Pohlemann Tim,
Veith Michael
Publication year - 2019
Publication title -
iet nanobiotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.366
H-Index - 38
eISSN - 1751-875X
pISSN - 1751-8741
DOI - 10.1049/iet-nbt.2018.5088
Subject(s) - fibroblast , nanostructure , aluminium , materials science , focal adhesion , biophysics , cell adhesion , nanotechnology , adhesion , cell , chemistry , composite material , biology , biochemistry , in vitro
The fibrotic encapsulation, which is mainly accompanied by an excessive proliferation of fibroblasts, is an undesired phenomenon after the implantation of various medical devices. Beside the surface chemistry, the topography plays also a major role in the fibroblast–surface interaction. In the present study, one‐dimensional aluminium oxide (1D Al 2 O 3 ) nanostructures with different distribution densities were prepared to reveal the response of human fibroblasts to the surface topography. The cell size, the cell number and the ability to form well‐defined actin fibres and focal adhesions were significantly impaired with increasing distribution density of the 1D Al 2 O 3 nanostructures on the substratum.