Open AccessSurfactant‐mediated synthesis of polyhydroxybutyrate (PHB) nanoparticles for sustained drug delivery
Author(s) -
Pachiyappan Senthilkumar,
Shanmuganatham Selvanantham Dawn,
Kuppa Sree Samanvitha,
Chandrasekaran Saipriya,
Samrot Antony Vincent
Publication year - 2019
Publication title -
iet nanobiotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.366
H-Index - 38
eISSN - 1751-875X
pISSN - 1751-8741
DOI - 10.1049/iet-nbt.2018.5053
Subject(s) - polyhydroxybutyrate , curcumin , pulmonary surfactant , nanoparticle , drug delivery , nuclear chemistry , chemistry , fourier transform infrared spectroscopy , nanomedicine , chemical engineering , nanotechnology , materials science , organic chemistry , biochemistry , bacteria , genetics , engineering , biology
In this study, polyhydroxybutyrate (PHB) nanoparticles were synthesised following nanoprecipitation method having different solvents and surfactant (Tween 80) concentrations. In this study, PHB nanoparticles were encapsulated with curcumin and subjected for sustained curcumin delivery. Both the curcumin loaded and unloaded PHB nanoparticles were characterised using FTIR, SEM, and AFM. Sizes of the particles were found to be between 60 and 300 nm. The drug encapsulation efficiency and in vitro drug release of the nanoparticles were analysed. Antibacterial activity and anticancer activity were also evaluated. The LC 50 values of most of the nanoparticles were found to be between 10 and 20 µg/100 µl, anticancer activity of curcumin loaded PHB nanoparticles were further confirmed by AO/PI staining and mitochondrial depolarisation assay.