Open AccessEffect of GNP functionalisation and multiple N ‐methylation of β ‐amyloid residue (32–37) on Gram‐positive bacterium
Author(s) -
Hemmaragala Nanjundaswamy Marishetty,
Abrahamse Heidi,
George Blassan P.
Publication year - 2017
Publication title -
iet nanobiotechnology
Language(s) - English
Resource type - Journals
ISSN - 1751-875X
DOI - 10.1049/iet-nbt.2016.0083
Subject(s) - enterococcus faecalis , bacteria , escherichia coli , staphylococcus aureus , klebsiella pneumoniae , pseudomonas aeruginosa , microbiology and biotechnology , antimicrobial , gram negative bacteria , gram positive bacteria , residue (chemistry) , pseudomonas , chemistry , biology , biochemistry , genetics , gene
In the previous report, the authors showed the gold nanoparticle (GNP) functionalised multiple N ‐methylated fragments of the residue (32–37) of beta ( β )‐amyloid protein (1–42), CGGIGLMVG and CIGLMVG toward disruption of β ‐amyloid (1–42), the predominant component of senile plaques. Herein the in vitro antimicrobial activities of both normal and multiple N ‐methylated sequences of CGGIGLMVG and CIGLMVG were screened and it was found that all the eight sequences including four (non‐functionalised with GNP) to possess activity against both Gram‐positive [ Staphylococcus aureus (ATCC 43300) and Enterococcus faecalis (ATCC 5129)] and Gram‐negative [Escherichia coli (ATCC 35218), Pseudomonas aeruginosa (ATCC 27853) and Klebsiella pneumoniae (ATCC 700603)] bacteria. Among them, N ‐methylated sequences CGGIGLMVG and CIGLMVG shown remarkable activity against Gram‐positive bacteria.