Open AccessBiocompatibility assessment of SiO 2 –TiO 2 composite powder on MG63 osteoblast cell lines for orthopaedic applications
Author(s) -
Chellappa Maniickam,
Thejaswini Bezawada,
Vijayalakshmi Uthirapathy
Publication year - 2017
Publication title -
iet nanobiotechnology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.366
H-Index - 38
eISSN - 1751-875X
pISSN - 1751-8741
DOI - 10.1049/iet-nbt.2016.0063
Subject(s) - biocompatibility , nanocomposite , materials science , composite number , crystallinity , acridine orange , biomaterial , fourier transform infrared spectroscopy , nanotechnology , osteoblast , chemical engineering , scanning electron microscope , composite material , chemistry , metallurgy , in vitro , apoptosis , biochemistry , engineering
The objective of this study is to evaluate the biocompatibility of composite powder consisting of silica and titania (SiO 2 –TiO 2 ) for biomedical applications. The advancement of nanoscience and nanotechnology encourages researchers to actively participate in reinvention of existing materials with improved physical, chemical and biological properties. Hence, a composite/hybrid material has given birth of new materials with intriguing properties. In the present investigation, SiO 2 –TiO 2 composite powder was synthesised by sol‐gel method and the prepared nanocomposite was characterised for its phase purity, functional groups, surface topography by powder X‐ray diffraction (XRD), Fourier transform infrared spectroscopy (FT‐IR) and scanning electron microscopy. Furthermore, to understand the adverse effects of composite, biocompatibility test was analysed by cell culture method using MG63 osteoblast cell lines as a basic screening method. From the results, it was observed that typical Si–O–Ti peaks in FT‐IR confirms the formation of composite and the crystallinity of the composite powder was analysed by XRD analysis. Further in vitro biocompatibility and acridine orange results have indicated better biocompatibility at different concentrations on osteoblast cell lines. On the basis of these observations, we envision that the prepared silica–titania nanocomposite is an intriguing biomaterial for better biomedical applications.