Open AccessEmerging microfluidic devices for cancer cells/biomarkers manipulation and detection
Author(s) -
PerezGonzalez Victor Hugo,
GalloVillanueva Roberto Carlos,
CamachoLeon Sergio,
GomezQuiñones Jose Isabel,
RodriguezDelgado Jose Manuel,
MartinezChapa Sergio Omar
Publication year - 2016
Publication title -
iet nanobiotechnology
Language(s) - English
Resource type - Journals
ISSN - 1751-875X
DOI - 10.1049/iet-nbt.2015.0060
Subject(s) - circulating tumor cell , microfluidics , nanotechnology , cancer , cancer biomarkers , dielectrophoresis , cancer detection , cancer cell , liquid biopsy , surface plasmon resonance , biomarker , materials science , metastasis , cancer research , chemistry , medicine , nanoparticle , biochemistry
Circulating tumour cells (CTCs) are active participants in the metastasis process and account for ∼90% of all cancer deaths. As CTCs are admixed with a very large amount of erythrocytes, leukocytes, and platelets in blood, CTCs are very rare, making their isolation, capture, and detection a major technological challenge. Microfluidic technologies have opened‐up new opportunities for the screening of blood samples and the detection of CTCs or other important cancer biomarker‐proteins. In this study, the authors have reviewed the most recent developments in microfluidic devices for cells/biomarkers manipulation and detection, focusing their attention on immunomagnetic‐affinity‐based devices, dielectrophoresis‐based devices, surface‐plasmon‐resonance microfluidic sensors, and quantum‐dots‐based sensors.