Open AccessEmpty nano and micro‐structured lipid carriers of virgin coconut oil for skin moisturisation
Author(s) -
Noor Norhayati Mohamed,
Khan Abid Ali,
Hasham Rosnani,
Talib Ayesha,
Sarmidi Mohamad Roji,
Aziz Ramlan,
Aziz Azila Abd
Publication year - 2016
Publication title -
iet nanobiotechnology
Language(s) - English
Resource type - Journals
ISSN - 1751-875X
DOI - 10.1049/iet-nbt.2015.0041
Subject(s) - coconut oil , sonication , stearic acid , voltage controlled oscillator , particle size , materials science , zeta potential , chemical engineering , chemistry , nanotechnology , chromatography , nanoparticle , composite material , food science , voltage , physics , quantum mechanics , engineering
Virgin coconut oil (VCO) is the finest grade of coconut oil, rich in phenolic content, antioxidant activity and contains medium chain triglycerides (MCTs). In this work formulation, characterisation and penetration of VCO‐solid lipid particles (VCO‐SLP) have been studied. VCO‐SLP were prepared using ultrasonication of molten stearic acid and VCO in an aqueous solution. The electron microscopy imaging revealed that VCO‐SLP were solid and spherical in shape. Ultrasonication was performed at several power intensities which resulted in particle sizes of VCO‐SLP ranged from 0.608 ± 0.002 µm to 44.265 ± 1.870 µm. The particle size was directly proportional to the applied power intensity of ultrasonication. The zeta potential values of the particles were from −43.2 ± 0.28 mV to −47.5 ± 0.42 mV showing good stability. The cumulative permeation for the smallest sized VCO‐SLP (0.608 µm) was 3.83 ± 0.01 µg/cm 2 whereas for larger carriers it was reduced (3.59 ± 0.02 µg/cm 2 ). It is concluded that SLP have the potential to be exploited as a micro/nano scale cosmeceutical carrying vehicle for improved dermal delivery of VCO.