Open AccessEvaluation of the effect of time on the distribution of zinc oxide nanoparticles in tissues of rats and mice: a systematic review
Author(s) -
Chen Aijie,
Feng Xiaoli,
Sun Ting,
Zhang Yanli,
An Shengli,
Shao Longquan
Publication year - 2016
Publication title -
iet nanobiotechnology
Language(s) - English
Resource type - Journals
ISSN - 1751-875X
DOI - 10.1049/iet-nbt.2015.0006
Subject(s) - zinc , kidney , nanoparticle , distribution (mathematics) , lung , chemistry , medicine , pathology , materials science , nanotechnology , metallurgy , mathematics , mathematical analysis
To evaluate the time effect on the distribution of zinc oxide nanoparticles (ZnO NPs) in tissues from rats and mice, a search on the PubMed, Embase, SpringerLink, Scopus, Science Direct, Cochrane, CNKI, Wanfang, and vip databases up to September 2014 was performed, followed by screening, data extraction, and quality assessment. Thirteen studies were included. At 24 h, Zn content was mainly distributed in the liver, kidney, and lung. At ≥7 days, Zn content was mainly distributed in the liver, kidney, lung, and brain. ZnO NPs are readily deposited in tissues. Furthermore, as time increases, Zn content decreases in the liver and kidney, but increases in the brain.