Open AccessElucidation on enhanced application of synthesised kojic acid immobilised magnetic and chitosan tri‐polyphosphate nanoparticles as antibacterial agents
Author(s) -
Chaudhary Jignesh,
Lakhawat Sudarshan,
Pathak Amrendra Nath
Publication year - 2015
Publication title -
iet nanobiotechnology
Language(s) - English
Resource type - Journals
ISSN - 1751-875X
DOI - 10.1049/iet-nbt.2014.0077
Subject(s) - chitosan , kojic acid , nanoparticle , chemistry , nuclear chemistry , antibacterial activity , polyphosphate , fourier transform infrared spectroscopy , aspergillus flavus , aspergillus niger , combinatorial chemistry , organic chemistry , bacteria , materials science , nanotechnology , biochemistry , chemical engineering , food science , phosphate , tyrosinase , biology , engineering , genetics , enzyme
Kojic acid (KA) is a secondary metabolite which is secreted by several aspergillus species. It is a multi‐functional skeleton from which many derivatives can be synthesised and applied in various areas of biotechnology. KA grafting on synthesised magnetic nanoparticles (MNPs) and chitosan tri‐polyphosphate (chitosan‐TPP) nanoparticles was successfully done and characterised by Fourier transformation infrared spectroscopy. It was observed that amino propyl triethoxy silane‐coated MNPs and chitosan‐TPP nanoparticles enhanced the antibacterial activity of KA against both Gram‐positive ( Staphylococcus aureus ) and Gram‐negative ( Pseudomonas aeruginosa ). The organic constitution and significant antibacterial activity of KA‐chitosan‐TPP nanoparticles can be applicable in the field of medical biotechnology.