Open AccessPreparation of spherical macroporous poly(lactic‐co‐glycolic acid) for bone tissue regeneration
Author(s) -
Bian Chunhui,
Lin Huiming,
Li Xiaofeng,
Ma Jie,
Jiang Pingping,
Qu Fengyu
Publication year - 2015
Publication title -
iet nanobiotechnology
Language(s) - English
Resource type - Journals
ISSN - 1751-875X
DOI - 10.1049/iet-nbt.2013.0066
Subject(s) - plga , glycolic acid , polyvinyl alcohol , materials science , scanning electron microscope , chemical engineering , poloxamer , emulsion , simulated body fluid , regeneration (biology) , drug delivery , tissue engineering , biomedical engineering , lactic acid , nuclear chemistry , chemistry , polymer , composite material , nanoparticle , nanotechnology , copolymer , medicine , biology , bacteria , microbiology and biotechnology , engineering , genetics
Spherical macroporous poly(lactic‐co‐glycolic acid) (PLGA) has been synthesised using an emulsion method. Polyvinyl alcohol and Pluronic F127 have been used as dispersing and porogen agent, respectively. The diameter of the spherical PLGA is about 20 μm and the pore size of the PLGA macroporous is about 2–2.5 μm observed by scanning electron microscopy. After immersing in simulated body fluid, the PLGA materials can induce the formation of hydroxyapatite (HAP) on their surface. The HAP‐PLGA has been obtained and used as the host for drug release. Furthermore, the drug‐loaded samples possess the various drug release performance by adjusting the thickness of the HAP layer. This highly satisfied composite material is expected to be promising in the applications in tissue regeneration engineering.