Open AccessFabrication of long‐acting drug release property of hierarchical porous bioglasses/polylactic acid fibre scaffolds for bone tissue engineering
Author(s) -
Wang Dan,
Lin Huiming,
Jiang Jingjie,
Jin Qumei,
Li Lei,
Dong Yan,
Qu Fengyu
Publication year - 2015
Publication title -
iet nanobiotechnology
Language(s) - English
Resource type - Journals
ISSN - 1751-875X
DOI - 10.1049/iet-nbt.2013.0011
Subject(s) - polylactic acid , mesoporous material , electrospinning , materials science , porosity , fabrication , chemical engineering , tissue engineering , scaffold , biomedical engineering , chemistry , composite material , polymer , organic chemistry , medicine , alternative medicine , pathology , engineering , catalysis
Hierarchical porous fibre scaffolds with mesoporous bioglasses (MBGs) and polylactic acid (PLA) were successfully fabricated by the electrospinning method. These compound scaffolds possess macropores with sizes of about 100 nm because of the solvent evaporation from the fibre and the mesoporous structure (∼4.0 nm) originated from MBGs. The biomineralisation ability was investigated in simulated body fluid. The fibre structure is beneficial for inducing the growth of hydroxyapatite. In addition, compared with pure MBGs, the materials (MP‐1 and MP‐2) exhibit a long‐acting drug release process up to 140 h and the drug release process corresponds with the Fickian diffusion mechanism. With the special fibre morphology and the hierarchical porous structure, the MBGs/PLA fibre scaffolds are expected to have potential application for bone tissue repair and regeneration.