Open AccessIrreversible magnetoporation of micro‐organisms in high pulsed magnetic fields
Author(s) -
Novickij Vitalij,
Grainys Audrius,
Novickij Jurij,
Markovskaja Svetlana
Publication year - 2014
Publication title -
iet nanobiotechnology
Language(s) - English
Resource type - Journals
ISSN - 1751-875X
DOI - 10.1049/iet-nbt.2013.0005
Subject(s) - electroporation , magnetic field , nanotechnology , biological specimen , biology , materials science , biophysics , physics , ecology , biochemistry , quantum mechanics , gene
Electroporation is an appealing way of stimulating living cells, which causes permanent or temporary nanoporosities in the structure of the biological objects. However, the technique has a disadvantage such as a requirement of contact between the electrodes and the cell medium. In this review, a methodology of contactless treatment of the biological objects using pulsed magnetic fields is proposed. The eukaryotic micro‐organisms Achlya americana and Saprolegnia diclina have been used in the study and magnetic fields up to 7 T were applied, which caused effects similar to irreversible electroporation resulting in the death of the species. The proposed technique is applicable for different types of the biological cells or micro‐organisms and possibly can be used in the area of cancer, antifungal treatment and other biotechnological fields.