Open AccessOne‐pot synthesis and functionalisation of Fe 2 O 3 @C‐NH 2 nanoparticles for imaging and therapy
Author(s) -
Li Xiaofeng,
Ding Jiabao,
Wang Xiaofeng,
Wei Kai,
Weng Jian,
Wang Jinan
Publication year - 2014
Publication title -
iet nanobiotechnology
Language(s) - English
Resource type - Journals
ISSN - 1751-875X
DOI - 10.1049/iet-nbt.2012.0015
Subject(s) - nanoparticle , aqueous solution , pyrene , polyethylene glycol , materials science , surface modification , thermal decomposition , magnetic nanoparticles , solubility , nuclear chemistry , amine gas treating , chemistry , inorganic chemistry , polymer chemistry , nanotechnology , organic chemistry
The authors have prepared amine‐modified Fe 2 O 3 @C nanoparticles with diameter of 20 nm by decomposing perchlorinated pyrene/Fe(NO 3 ) 3 mixture in the presence of ammonia in solvothermal conditions at 180°C for 48 h by a one‐step process. NH 3 is not only a cocatalyst of Fe(NO 3 ) 3 for decomposition of perchlorinated pyrene, but also the source of surface functionalisation group. The effect of synthesis conditions on shape and size of nanoparticles and characterisation of their structure and functionalisation group are investigated in this research. The amino group in the surface of core–shell nanoparticles can be further functionalised with polyethylene glycol and folic acid to improve their solubility in aqueous solution and target cancer cells. The applications of functionalised core–shell nanoparticles in magnetic resonance imaging and cancer thermal therapy are also investigated in this research.