Open AccessGenome‐scale model of C. autoethanogenum reveals optimal bioprocess conditions for high‐value chemical production from carbon monoxide
Author(s) -
Norman Rupert O.J.,
Millat Thomas,
Schatschneider Sarah,
Henstra Anne M.,
Breitkopf Ronja,
Pander Bart,
Annan Florence J.,
Piatek Pawel,
Hartman Hassan B.,
Poolman Mark G.,
Fell David A.,
Winzer Klaus,
Minton Nigel P.,
Hodgman Charlie
Publication year - 2019
Publication title -
engineering biology
Language(s) - English
Resource type - Journals
ISSN - 2398-6182
DOI - 10.1049/enb.2018.5003
Subject(s) - bioprocess , carbon monoxide , biochemical engineering , production (economics) , scale (ratio) , diversification (marketing strategy) , chemistry , process engineering , environmental science , chemical engineering , organic chemistry , engineering , physics , business , catalysis , economics , quantum mechanics , marketing , macroeconomics
Clostridium autoethanogenum is an industrial microbe used for the commercial‐scale production of ethanol from carbon monoxide. While significant progress has been made in the attempted diversification of this bioprocess, further improvements are desirable, particularly in the formation of the high‐value platform chemicals such as 2,3‐butanediol (2,3‐BD). A new, experimentally parameterised genome‐scale model of C. autoethanogenum predicts dramatically increased 2,3‐BD production under non‐carbon‐limited conditions when thermodynamic constraints on hydrogen production are considered.