Low‐noise wide‐bandwidth DNA readout instrument for nanopore applications | Zendy

Yun J. | Zendy; Choi H. | Zendy; Kim J. | Zendy

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Low‐noise wide‐bandwidth DNA readout instrument for nanopore applications

Author(s) -

Yun J.,

Choi H.,

Kim J.

Publication year - 2017

Publication title -

electronics letters

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 0.375

H-Index - 146

ISSN - 1350-911X

DOI - 10.1049/el.2017.0870

Subject(s) - transimpedance amplifier , resistor , parasitic capacitance , bandwidth (computing) , capacitance , resistive touchscreen , electronic engineering , amplifier , optoelectronics , nanopore , electrical engineering , low noise amplifier , noise (video) , materials science , engineering , computer science , operational amplifier , physics , nanotechnology , telecommunications , electrode , voltage , quantum mechanics , artificial intelligence , image (mathematics)

A low‐noise, wide‐bandwidth DNA readout instrument for nanopore applications is presented. Owing to hardware simplicity and reliability, a resistive‐feedback transimpedance amplifier ( rf ‐TIA) is adopted as the headstage for the readout instrument. However, to achieve a high gain and low input noise, its high feedback resistance induces a high parasitic capacitance, thus significantly limiting the 3 dB bandwidth. To drastically reduce the parasitic capacitance and widen the bandwidth, a novel rf ‐TIA architecture is fabricated that utilises a split‐resistor technique for the high feedback resistor. This is demonstrated in a benchtop test employing an α‐haemolysin nanopore.

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