Open AccessRheological monitoring of tau protein polymerisation with acoustic waves sensor
Author(s) -
Didier P.,
Razan F.,
Caplain E.,
Michiel M.,
Delamarche C.,
Nogues C.,
Le Huerou J.Y.,
Serfaty S.,
Larzabal P.
Publication year - 2017
Publication title -
electronics letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.375
H-Index - 146
eISSN - 1350-911X
pISSN - 0013-5194
DOI - 10.1049/el.2016.3400
Subject(s) - resonator , acoustics , viscoelasticity , tau protein , shear (geology) , polymerization , rheology , acoustic wave , sensitivity (control systems) , materials science , moduli , physics , composite material , electronic engineering , alzheimer's disease , engineering , optoelectronics , disease , medicine , polymer , pathology , quantum mechanics
Among acoustic waves sensors, the thickness shear mode resonator presents high sensitivity for the measurement of liquid viscoelastic properties, enabling the monitoring of the shear moduli, G ′ G ″, by using a suitable physical model. The development of an instrumental system for detecting the tau protein involved in Alzheimer's disease is proposed which will aid in understanding the mechanisms of this disease. The tau protein is present in complex products such as blood and cerebrospinal fluid. The experimental results show that the acoustic wave system allows to differentiate between tau protein solutions with different states of polymerisation.