Open AccessCMOS‐based implantable glucose monitoring device with improved performance and reduced invasiveness
Author(s) -
Kawamura T.,
Masuda K.,
Hirai T.,
Ohta Y.,
Motoyama M.,
Takehara H.,
Noda T.,
Sasagawa K.,
Tokuda T.,
Okitsu T.,
Takeuchi S.,
Ohta J.
Publication year - 2015
Publication title -
electronics letters
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.375
H-Index - 146
eISSN - 1350-911X
pISSN - 0013-5194
DOI - 10.1049/el.2015.0612
Subject(s) - cmos , sensitivity (control systems) , biomedical engineering , reduction (mathematics) , electronic engineering , materials science , optoelectronics , engineering , geometry , mathematics
An implantable glucose monitoring device based on a CMOS line sensor combined with a glucose‐responsive fluorescent hydrogel is developed. An implantable glucose monitoring device with sufficient sensitivity and response time is realised, which is an improvement over the authors' previous proof‐of‐concept device. A reduction of the sensor size made the device diameter injectable with a commercially available 16‐gauge syringe needle. The sensor's performance was confirmed through both in vitro and in vivo experiments.