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Macrophages of Human First Trimester Decidua Express Markers Associated to Alternative Activation
Author(s) -
Cupurdija Kristijan,
Azzola Dagmar,
Hainz Ursula,
Gratchev Alexei,
Heitger Andreas,
Takikawa Osamu,
Goerdt Sergij,
Wintersteiger Reinhold,
Dohr Gottfried,
Sedlmayr Peter
Publication year - 2004
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1046/j.8755-8920.2003.00128.x
Subject(s) - decidua , flow cytometry , phenotype , immune system , immunology , biology , macrophage , immunohistochemistry , phagocytosis , microbiology and biotechnology , fetus , placenta , pregnancy , in vitro , gene , genetics , biochemistry
Problem: Depending on the type of their activation, macrophages may promote T H 1‐ or T H 2‐type of immune responses. To date, not much is known about the activation phenotype of decidua macrophages, which – together with NK cells – constitute the majority of bone marrow derived cells at this location. Method of study: The study was based on analysis of healthy first trimester decidua by immunohistochemistry and flow cytometry. We analyzed expression of markers characteristic for alternatively activated macrophages (M φ 2). Results: The markers MS‐1 (stabilin‐1) and coagulation factor XIIIa were found expressed in the interior of decidua macrophages (DM φ ). In contrast, indoleamine 2,3‐dioxygenase (IDO), an enzyme induced in macrophages by IFN γ , was not present in DM φ . Conclusions: First trimester DM φ display phenotypic markers associated to alternatively activated macrophages. In addition, absence of IDO indicates that DM φ are not under a predominant influence of IFN γ .