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γ/δT‐cell Subsets, NKG2A Expression and Apoptosis of Vδ2+ T cells in Pregnant Women with or without Risk of Premature Pregnancy Termination
Author(s) -
Szereday Laszlo,
Barakonyi Aliz,
Miko Eva,
Varga Peter,
SzekeresBartho Julia
Publication year - 2003
Publication title -
american journal of reproductive immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.071
H-Index - 97
eISSN - 1600-0897
pISSN - 1046-7408
DOI - 10.1046/j.8755-8920.2003.00107.x
Subject(s) - pregnancy , apoptosis , andrology , medicine , obstetrics , immunology , biology , genetics
Problem: Potentially cytotoxic V δ 2+ T lymphocytes recognize human leukocyte antigen‐E on the trophoblast via their CD94/NKG2A receptors. This study aims at determing the percentage of γ / δ T‐cell subsets, their NKG2A and Annexin V positivity in peripheral blood of healthy pregnant women and women at risk of premature pregnancy termination. Method of Study: Peripheral V δ 2+ cells from healthy pregnant women and from women at risk of premature pregnancy termination were tested for the KIR NKG2A and Annexin V positivity by flow cytometry. Results: The percentage of viable V δ 2+ T cells was higher, that of V δ 1+ T cells was lower in women at risk of premature pregnancy termination than in healthy pregnant women. The percentage of NKG2A+ V δ 2+ T cells was significantly lower in pregnant women at risk of premature pregnancy termination than in normal pregnancy. Conclusions: These data suggest the involvement of γ / δ T lymphocytes in the pathogenesis of premature pregnancy termination.