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Preemptive Renal Transplantation: Why Not?
Author(s) -
Mange Kevin C.,
Weir Matthew R.
Publication year - 2003
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1046/j.1600-6143.2003.00232.x
Subject(s) - medicine , intensive care medicine , transplantation , dialysis , observational study , renal replacement therapy , end stage renal disease , kidney transplantation , disease , surgery
Dialysis has been the long‐established initial choice of treatment for persons with end‐stage renal disease. Transplantation before dialysis, or preemptive renal transplantation (PRT), has been controversial because of the paucity of clinical evidence that has clarified the benefits vs. risks of this approach. However, several recent observational analyses indicate that PRT is the optimal strategy to benefit patients requiring renal replacement therapy. This current review will discuss the advantages that are associated with PRT, and will summarize studies that have investigated the impact of the timing of transplantation on outcomes. We will also discuss the utility of PRT from various perspectives, and describe the challenges ahead in expanding the opportunity of PRT for more patients .