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Cytomegalovirus (CMV) Resistance to Antivirals
Author(s) -
Drew W. Lawrence,
Paya Carlos V.,
Emery Vincent
Publication year - 2001
Publication title -
american journal of transplantation
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.89
H-Index - 188
eISSN - 1600-6143
pISSN - 1600-6135
DOI - 10.1046/j.1600-6135.2001.00000.x
Subject(s) - medicine , cytomegalovirus , virology , drug resistance , clinical trial , human cytomegalovirus , immunology , virus , herpesviridae , viral disease , biology , microbiology and biotechnology
This article reviews the biology of cytomegalovirus (CMV), the approved antiviral therapies, and mechanisms of resistance to these drugs. The rates of resistance development in clinical trials are presented, as are the assays for testing susceptibility by phenotypic and genotypic methods. Factors that favor the development of clinical and in vitro antiviral resistance are discussed. Finally, approaches to altering antiviral therapy as resistance develops are outlined.