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Amphetamine enhances training‐induced motor cortex plasticity
Author(s) -
Tegenthoff M.,
Cornelius B.,
Pleger B.,
Malin J.P.,
Schwenkreis P.
Publication year - 2004
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1046/j.1600-0404.2003.00235.x
Subject(s) - amphetamine , motor cortex , neuroscience , primary motor cortex , transcranial magnetic stimulation , neuroplasticity , psychology , glutamatergic , cortex (anatomy) , medicine , stimulation , dopamine , glutamate receptor , receptor
Objectives – Repetitive synchronized movements lead to short‐term plastic changes in the primary motor cortex, which can be assessed by transcranial magnetic stimulation (TMS). Drugs which enhance such plastic changes could be of therapeutical interest, e.g. in patients with cerebral lesions. Material and methods – We studied the effect of amphetamine on motor performance and plastic changes in the motor cortex as revealed by TMS mapping in healthy humans, who had to train a repetitive synchronized movement over 1 h. Results – Cortical plastic changes observed after 1 h of training were more pronounced with amphetamine, whereas motor performance did not differ between training sessions with and without amphetamine. Conclusion – We conclude that amphetamine is able to enhance training‐induced motor cortex plasticity. This effect could be due to its known influence on the GABAergic and glutamatergic system, but might also result from its role as an indirect catecholaminergic agonist.