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Serum neuron‐specific enolase, prolactin, and creatine kinase after epileptic and psychogenic non‐epileptic seizures
Author(s) -
Willert C.,
Spitzer C.,
Kusserow S.,
Runge U.
Publication year - 2004
Publication title -
acta neurologica scandinavica
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.967
H-Index - 95
eISSN - 1600-0404
pISSN - 0001-6314
DOI - 10.1046/j.1600-0404.2003.00232.x
Subject(s) - enolase , epilepsy , psychogenic disease , creatine kinase , prolactin , medicine , electroencephalography , epileptic seizure , endocrinology , psychology , neuroscience , psychiatry , hormone , immunohistochemistry
Purpose – To evaluate the discriminative power of serial, simultaneous determinations of serum neuron‐specific enolase (NSE), prolactin (PRL) and creatine kinase (CK) in differentiating psychogenic non‐epileptic seizures (PNES) from epileptic seizures (ES). Methods – Prospective measurement of the three markers after 44 single seizures (32 ES and 12 PNES) during continuous video‐EEG monitoring at seven different sampling points. Results – Patients with ES had a significantly greater increase in PRL at 10, 20, 30 min, 1 and 6 h. The sensitivity for elevated NSE and CK was low. PRL showed a higher sensitivity. However, the corresponding positive predictive value was lower than in CK and NSE. Additionally, PRL had the lowest specificity of all parameters. Conclusions – The limited discriminative power of PRL, CK, and NSE calls into question if these markers are helpful in differentiating PNES and ES.