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Long‐Term Results of Cardiac Transplantation
Author(s) -
Juffe Alberto,
Rodriguez Miguel A.,
Caputo Enrico,
Cuenca Jose,
Crespo Marisa
Publication year - 2003
Publication title -
journal of cardiac surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.428
H-Index - 58
eISSN - 1540-8191
pISSN - 0886-0440
DOI - 10.1046/j.1540-8191.2003.02024.x
Subject(s) - medicine , term (time) , transplantation , intensive care medicine , heart transplantation , cardiology , physics , quantum mechanics
Heart transplantation is a successful therapeutic option for patients with end‐stage heart cardiomyopathy. From April 1991 to December 2000, 345 patients underwent heart transplantation at the Juan Canalejo Hospital. The mean age of recipients was 54.5 ± 11.4 years ; 286 (83%) were male patients. Idiopathic (52.2%) and ischemic (34.9%) end‐stage cardiomyopathy were the main causes leading to transplantation. Ninety‐four patients had undergone a previous heart operation. The mean left ventricular ejection fraction was 22.8 ± 11.4 . Forty patients (11.5%) were transplanted in urgent (status I) condition. The mean time spent on the waiting list was 35.9 days. In‐hospital mortality was 10.6% and 24% for transplantations performed on an elective and urgent basis, respectively. Operative (30‐day), one‐year and six‐year survival was 87.2%, 81.3% and 64%, respectively. In terms of actuarial survival, there were no significant differences with regard to the recipient's age, sex, previous cardiac surgery, and the etiology of the end‐stage cardiomyopathy. The six‐year actuarial survival for recipients receiving hearts from female donors was 59% compared with 72% for male donors (p = 0.05) . There has been a low incidence of rejection, as well as cardiac graft vasculopathy. Actuarial survival at six years was 66% for patients transplantated on an elective basis compared with 57% for patients transplanted on an urgent basis (p = 0.04) . The aim of the study was to evaluate long‐term results for patients who underwent orthotopic heart transplantation. In our experience, status I is associated with a higher mortality. (J Card Surg 2003;18:183‐189)