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Exogenous CGRP Improves Coronary Microcirculation After Myocardial Reperfusion Associated with Cardiopulmonary Bypass
Author(s) -
Li Xin,
Chen Zhanggen,
Jia Bing,
Zhong Hui,
Ye Ming,
Hui Wei,
Jin Huiming
Publication year - 2002
Publication title -
journal of cardiac surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.428
H-Index - 58
eISSN - 1540-8191
pISSN - 0886-0440
DOI - 10.1046/j.1540-8191.2002.101410.x
Subject(s) - calcitonin gene related peptide , medicine , cardiopulmonary bypass , microvessel , cardiology , blood flow , perfusion , vasodilation , microcirculation , anesthesia , ischemia , calcitonin , angiogenesis , neuropeptide , receptor
Background: Calcitonin gene‐related peptide (CGRP) is known to have an extremely potent and prolonged vasodilator effect on the coronary arteries. Studies have shown that CGRP increased coronary blood flow and alleviated reperfusion injury in vitro. It is still unknown, however, whether exogenous CGRP has a protective effect on the reperfusion heart associated with cardiopulmonary bypass (CPB). Methods: An in vivo porcine model of CPB was established. Twenty pigs, 10 controls and 10 CGRP used animals (CGRP group), were performed a median sternotomy followed by a standard CPB. All the hearts were arrested for 45 minutes. In the CGRP group, 1mg/kg CGRP was added into the cardioplegia, and another 1mg/kg was reperfused just before the aortic cross‐clamp was removed. In both groups, myocardial microvascular perfusion, coronary arterial microvessel diameter and microvessel blood flow were detected by a laser doppler flowmeter and a contact microscope with TV monitor on five consecutive time perioperatively. Result: Myocardial microvascular perfusion was significantly higher and coronary arterial microvessel diameter was larger in the CGRP group on every point of time of reperfusion compared to those in the control group. In the CGRP group, microvessel blood flow also improved significantly than that in the control group during reperfusion. Conclusion: CGRP improves myocardial microcirculation during cardiac ischemia‐reperfusion associated with CPB and could become a new, potent myocardial protector.