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Systematic Organ Protection in Coronary Artery Surgery With or Without Cardiopulmonary Bypass
Author(s) -
Wan Song,
Yim Anthony P.C.,
Ng Calvin S.H.,
Arifi Ahmed A.
Publication year - 2002
Publication title -
journal of cardiac surgery
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.428
H-Index - 58
eISSN - 1540-8191
pISSN - 0886-0440
DOI - 10.1046/j.1540-8191.2002.01010.x
Subject(s) - medicine , cardiopulmonary bypass , artery , cardiology , limiting , bypass grafting , inflammatory response , revascularization , incidence (geometry) , inflammation , myocardial infarction , mechanical engineering , physics , optics , engineering
Coronary artery bypass grafting with cardiopulmonary bypass (CPB) is known to be associated with a systemic inflammatory response, which contributes to the development of postoperative complications including multiple organ dysfunction. Off‐pump coronary surgery has been shown to attenuate the inflammatory injury compared to the conventional approach, thereby reducing the incidence of postoperative cardiopulmonary, renal, or neurological dysfunction. It is believed that off‐pump experience may greatly impact on improving the outcome of coronary surgery in certain high‐risk patients. Moreover, a better understanding of the underlying mechanism would also help to improve our current CPB management. Accumulating evidence to date indicates that a balance between pro‐ and antiinflammatory responses is crucial in limiting the extent of such systemic inflammatory injury following surgical myocardial revascularization.