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Comparison of Echocardiography with Technetium 99m‐Gated Single Photon Emission Computed Tomography as Diagnostic Tools for Left Ventricular Ejection Fraction
Author(s) -
Choragudi Nagaraju L.,
Prakash Anita M.,
Sun Ying,
Prasad Paturu,
Chiaramida Salvatore A.,
Lucariello Richard J.
Publication year - 2001
Publication title -
echocardiography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.404
H-Index - 62
eISSN - 1540-8175
pISSN - 0742-2822
DOI - 10.1046/j.1540-8175.2001.00627.x
Subject(s) - ejection fraction , nuclear medicine , receiver operating characteristic , medicine , confidence interval , linear regression , single photon emission computed tomography , technetium , echo (communications protocol) , bland–altman plot , limits of agreement , cardiology , mathematics , statistics , heart failure , computer science , computer network
Left ventricular ejection fractions (LVEF) are routinely measured and result in critical decisionmaking algorithms in cardiology. This study was conducted to compare the accepted standard two‐dimensional (2‐D) echocardiogram ejection fraction (EF ECHO ) with single photon emission computed tomography rest ejection fraction (EF SPECT ). Data were acquired and analyzed from 51 inpatients. EF ECHO was obtained using modified Simpson's rule in the four‐chamber apical view, and gated EF SPECT was computed by an automated method (Siemens ICON software). Comparison between EF ECHO and EF SPECT was done by linear regression, Bland‐Altman, and receiver operator characteristic (ROC) analyses. Linear regression analysis revealed EF SPECT = 1.12 × EF ECHO − 3.6%, r = 0.93, n = 51, P < 0.0001 . Bland‐Altman analysis showed that the limits of 95% confidence for the difference between EF SPECT and EF ECHO were − 12% to 18%. Ninety‐eight percent of the datapoints were within the limits of confidence. The ROC analysis showed that the sensitivity and specificity for detecting abnormal EF (≤ 50%) were 85% and 86% with EF SPECT , and 91% and 90% with EF ECHO . This study showed good correlation as well as agreement between SPECT and two‐dimensional echocardiograms in measuring EF.