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Left Ventricular Apical Thrombus and Myocardial Viability: A Dobutamine Stress Echocardiographic Study
Author(s) -
Cusick David A.,
Bonow Robert O.,
Chaudhry Farooq A.
Publication year - 2000
Publication title -
echocardiography
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.404
H-Index - 62
eISSN - 1540-8175
pISSN - 0742-2822
DOI - 10.1046/j.1540-8175.2000.00547.x
Subject(s) - cardiology , thrombus , medicine , ejection fraction , left ventricular thrombus , dobutamine , coronary artery disease , heart failure , hemodynamics
The objective of this article was to determine whether the presence of left ventricular apical thrombus is a marker of nonviable myocardium. Reduced coronary blood flow secondary to atherosclerosis may result in chronic reversible left ventricular wall‐motion abnormalities. Severe regional abnormalities also predispose to formation of left ventricular thrombus. The relationship between left ventricular apical thrombus and myocardial viability has not been previously described. Eighty patients with coronary artery disease and chronic left ventricular dysfunction were studied by dobutamine stress echocardiography. Left ventricular apical thrombus was identified using echocardiographic criteria. Wall‐motion analysis was performed using a standard 16‐segment model and ejection fraction was calculated. As a result, 48 patients (60%) had definite or highly suspicious findings for left ventricular thrombus (group 1), and 32 patients (40%) had no thrombus (group 2). Group 1 had significantly higher composite ( 54.0 ± 5.8 vs 43.3 ± 6.4 ) and apical ( 6.0 ± 2.7 vs 12.4 ± 3.4 ) wall‐motion scores compared to those in group 2 ( P = 0.01 ). Thirty‐two patients (67%) in group 1 demonstrated no contractile reserve in the apical segments, consistent with lack of viability, versus eight patients (25%) in group 2 ( P = 0.0003 ). The number of viable apical segments per patient was significantly less in group 1 ( 0.7 ± 1.2 ) versus group 2 ( 1.8 ± 1.3 ) ( P = 0.01 ). Left ventricular apical thrombus is more likely to be present when there is absence of myocardial viability in the corresponding segments.