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Quantification of Fatty Tissue Mass by Magnetic Resonance Imaging in Arrhythmogenic Right Ventricular Dysplasia
Author(s) -
FATTORI ROSSELLA,
TRICOCI PIERLUIGI,
RUSSO VINCENZO,
LOVATO LUIGI,
BACCHIREGGIANI LETIZIA,
GAVELLI GIAMPAOLO,
BRANZI ANGELO,
BORIANI GIUSEPPE
Publication year - 2005
Publication title -
journal of cardiovascular electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.193
H-Index - 138
eISSN - 1540-8167
pISSN - 1045-3873
DOI - 10.1046/j.1540-8167.2004.40498.x
Subject(s) - arrhythmogenic right ventricular dysplasia , medicine , magnetic resonance imaging , pathological , cardiology , dysplasia , radiology , cardiomyopathy , heart failure
Arrhythmogenic right ventricular dysplasia (ARVD) is a heart muscle disorder in which the pathological substrate is a fatty or fibro‐fatty replacement of the right ventricular (RV) myocardium. Methods and Results: Magnetic resonance imaging (MRI) studies were performed in 10 patients with arrhythmogenic right ventricular dysplasia and in 24 matched controls in order to assess right ventricular epicardial/intramyocardial fatty tissue mass, RV myocardial mass, and RV functional parameters. Functional abnormalities were found in all ARVD cases. Patients with ARVD showed increased fatty tissue compared to controls (8.2 ± 4 g vs. 2.0 ± 1.0 g; P = 0.001), whereas no significant differences were found in RV myocardial mass (29.5 ± 9.2 g vs. 23.2 ± 6.7 g; P = NS). A correlation coefficient between 0.87 and 0.97 was found for repeated measurements. Conclusion: Quantification of fatty tissue with MRI is feasible and constitutes an objective method for differentiating normal from pathological conditions. This approach may lead to a complete diagnostic assessment of ARVD with the potential application for monitoring the evolution of the disease.