Case of Polymorphic Ventricular Tachycardia in Diphenhydramine Poisoning | Zendy

JOSHI AJAY K. | Zendy; SLJAPIC TATJANA | Zendy; BORGHEI HASSAN | Zendy; KOWEY PETER R. | Zendy

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Case of Polymorphic Ventricular Tachycardia in Diphenhydramine Poisoning

Author(s) -

JOSHI AJAY K.,

SLJAPIC TATJANA,

BORGHEI HASSAN,

KOWEY PETER R.

Publication year - 2004

Publication title -

journal of cardiovascular electrophysiology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.193

H-Index - 138

eISSN - 1540-8167

pISSN - 1045-3873

DOI - 10.1046/j.1540-8167.2004.03173.x

Subject(s) - medicine , torsades de pointes , proarrhythmia , qt interval , diphenhydramine , ventricular tachycardia , anesthesia , population , cardiology , cardioversion , atrial fibrillation , environmental health , histamine

This is the first reported case of torsades de pointes attributable to diphenhydramine, a drug with weak I Kr effects. A 26‐year‐old, healthy man was admitted to intensive care after a diphenhydramine overdose. Results of physical examination, ECG, and electrolytes were normal at admission. Despite supportive care, he developed typical, sustained, torsades de pointes with a markedly prolonged QT interval requiring cardioversion. Drugs with weak I Kr ‐blocking effects may cause lethal proarrhythmia in susceptible individuals when delivered in high concentrations. This case illustrates the variation in repolarization reserve that exists in a free‐standing population. (J Cardiovasc Electrophysiol, Vol. 15, pp. 591‐593, May 2004)

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