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Mechanism of Ventricular Arrhythmias in the Long QT Syndrome: On Hermeneutics
Author(s) -
ELSHERIF NABIL
Publication year - 2001
Publication title -
journal of cardiovascular electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.193
H-Index - 138
eISSN - 1540-8167
pISSN - 1045-3873
DOI - 10.1046/j.1540-8167.2001.00973.x
Subject(s) - torsades de pointes , medicine , afterdepolarization , cardiology , repolarization , long qt syndrome , ventricular tachycardia , reentry , qrs complex , qt interval , electrophysiology
VT Mechanisms in LQTS. Both the congenital and acquired long QT syndrome are due to abnormalities (intrinsic and/or acquired) of the ionic currents underlying repolarization. The prolongation of repolarization acts as a priming step for the generation of early afterdepolarizations. In the long QT syndrome, it also is associated with increased dispersion of repolarization. Focal early afterdepolarization‐induced triggered beat(s) can infringe on the underlying substrate of inhomogeneous repolarization to initiate polymorphic reentrant ventricular tachycardia that sometimes has a characteristic twisting of the QRS axis, referred to as torsades de pointes.