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Myocardial Ischemia: What Factors Determine Arrhythmogenesis?
Author(s) -
CASCIO WAYNE E.
Publication year - 2001
Publication title -
journal of cardiovascular electrophysiology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.193
H-Index - 138
eISSN - 1540-8167
pISSN - 1045-3873
DOI - 10.1046/j.1540-8167.2001.00726.x
Subject(s) - reentry , medicine , cardiology , ischemia , ventricular fibrillation , myocardial ischemia , fibrillation , neuroscience , atrial fibrillation , biology
Arrhythmia Formation in Ischemic Heart. In ischemic myocardium, cellular architecture and heterogeneous changes in metabolic and ionic conditions interact to cause spatial and temporal heterogeneity of electrical properties predisposing to lethal ventricular arrhythmias. Yet, the details of their interaction, vis‐à‐vis the initiation and maintenance of reentry, remain poorly understood. Future studies are needed to address the mechanisms of the initial premature beat, reentry, and formation of wavebreaks contributing to ventricular fibrillation. New experimental methods including mathematical and transgenic mouse models are promising techniques to study these phenomena and thereby provide new insights into the fundamental mechanisms of ischemia‐related arrhythmias.