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Effect of low‐molecular‐weight fucoidan on experimental arterial thrombosis in the rabbit and rat
Author(s) -
ColliecJouault S.,
Millet J.,
Helley D.,
Sinquin C.,
Fischer A. M.
Publication year - 2003
Publication title -
journal of thrombosis and haemostasis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.947
H-Index - 178
eISSN - 1538-7836
pISSN - 1538-7933
DOI - 10.1046/j.1538-7836.2003.t01-1-00215.x
Subject(s) - fucoidan , heparin , antithrombotic , antithrombin , heparin cofactor ii , pharmacology , thrombin , chemistry , anticoagulant , thrombus , partial thromboplastin time , jugular vein , medicine , biochemistry , endocrinology , platelet , polysaccharide
was used to perform an extra-corporeal arteriovenous shunt between the carotid artery and the jugular vein ; mean times for formation of an occlusive thrombus in the carotid artery were determined in control and treated animals. Both fucoidan and unfractionated heparin, injected intravenously 5 min before thrombosis induction, inhibited thrombus formation significantly. LMW fucoidan and heparin increased mean time-to-occlusion about three-fold in the same concentration range (2 mg/kg fucoidan 43.7 + 5.5 min and 1 mg/kg heparin 55.4 + 2.6 versus control 15.6 + 1.6 min ; 5 animals per group ; p < 0.001). The anti-thrombotic effect of fucoidan was also evaluated in this model after subcutaneous injection 2 h before thrombosis induction. With a dose of 7.5 mg/kg, time-to-occlusion was prolonged significantly (22.8 + 3.4 min in the treated group