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Comparison among natural (Arg 304 Gln, Arg 304 Trp) and artificial (Arg 290 His, Arg 290 Lys) mutations in coagulation factor VII loops
Author(s) -
Furlan Freguia C.,
Toso R.,
Pinotti M.,
Gemmati D.
Publication year - 2003
Publication title -
journal of thrombosis and haemostasis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.947
H-Index - 178
eISSN - 1538-7836
pISSN - 1538-7933
DOI - 10.1046/j.1538-7836.2003.0468e.x
Subject(s) - tissue factor , factor vii , coagulation , serine protease , factor ix , chemistry , factor viia , serine , coagulation disorder , proteases , biochemistry , protease , medicine , enzyme
Our study provide information on FVII residue important for interaction with substrates and cofactors. Moreover, the comparison of the in vitro and in vivo mutations, potentially affecting the identical residues encoded by putative hot spot mutational sites, help to interpretate unexpected differences in the incidence of FVII variants within the population