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The rediscovery and isolation of TFPI
Author(s) -
Broze G. J.
Publication year - 2003
Publication title -
journal of thrombosis and haemostasis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.947
H-Index - 178
eISSN - 1538-7836
pISSN - 1538-7933
DOI - 10.1046/j.1538-7836.2003.00391.x
Subject(s) - tissue factor pathway inhibitor , tissue factor , coagulation , isolation (microbiology) , mechanism of action , chemistry , biochemistry , biology , medicine , bioinformatics , in vitro
Summary. Tissue factor pathway inhibitor (TFPI) is a multivalent Kunitz‐type proteinase inhibitor that produces factor (F)Xa‐dependent feedback inhibition of the factor VIIa/tissue factor (FVIIa/TF) catalytic complex that is responsible for the initiation of coagulation. Since 1985, when Rapaport and colleagues reported that the lipoprotein fraction of plasma contained a FXa‐dependent inhibitor of FVIIa/TF, myriad articles have established its biochemical structure, its mechanism of action, and its physiological importance. This brief personal account reviews historical studies that established the existence of the inhibitor and the events that led to its initial isolation.