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Integration of vascular biology and magnetic resonance imaging in the understanding of atherothrombosis and acute coronary syndromes
Author(s) -
Fuster V.,
Corti R.,
Fayad Z. A.,
Schwitter J.,
Badimon J. J.
Publication year - 2003
Publication title -
journal of thrombosis and haemostasis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.947
H-Index - 178
eISSN - 1538-7836
pISSN - 1538-7933
DOI - 10.1046/j.1538-7836.2003.00271.x
Subject(s) - medicine , acute coronary syndrome , cardiology , thrombus , vulnerable plaque , magnetic resonance imaging , vulnerability (computing) , inflammation , pathophysiology , intensive care medicine , myocardial infarction , radiology , computer security , computer science
Summary. The interaction between the vulnerable atherosclerotic plaque prone to disruption and thrombus formation is the cornerstone of acute coronary syndrome (ACS). Although distinct from one another, the atherosclerotic and thrombotic processes appear to be interdependent, hence the term atherothrombosis. Inflammation is a crucial common pathophysiological mechanism. Overall, the association of plaque vulnerability and ACS has been well documented. Given the multifactorial origin of atherothrombosis the best preventive approach should be aggressive management of all the risk factors. New interventions should be directed toward decreasing vulnerability of the lesions thereby decreasing the risk of ACS.