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Hepatic infarctions during pregnancy are associated with the antiphospholipid syndrome and in addition with complete or incomplete HELLP syndrome
Author(s) -
Pauzner R.,
Dulitzky M.,
Carp H.,
Mayan H.,
Kenett R.,
Farfel Z.,
Many A.
Publication year - 2003
Publication title -
journal of thrombosis and haemostasis
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.947
H-Index - 178
eISSN - 1538-7836
pISSN - 1538-7933
DOI - 10.1046/j.1538-7836.2003.00253.x
Subject(s) - hellp syndrome , medicine , antiphospholipid syndrome , pregnancy , hemolysis , eclampsia , lupus anticoagulant , elevated liver enzymes , concomitant , gastroenterology , obstetrics , immunology , antibody , genetics , biology
Summary. Antiphospholipid antibody syndrome (APS) is associated with adverse pregnancy outcomes and maternal complications including thrombotic events and early pre‐eclampsia. HELLP syndrome (Hemolysis, Elevated Liver enzymes, Low Platelets) represents a unique form in the spectrum of pre‐eclampsia. This report describes four patients with pregnancy‐associated hepatic infarctions. All four had APS and HELLP syndrome, which was complete in one patient and incomplete in three patients, with elevated liver enzymes in all, and either thrombocytopenia or hemolysis in two. In the literature, we found descriptions of an additional 24 patients who had 26 pregnancies with concomitant hepatic infarction. Of the total 28 patients, anticardiolipin antibodies (aCL) and/or lupus anticoagulant (LAC) were assessed in 16 patients, out of whom 15 were found to be positive. Hepatic infartction during pregnancy was associated almost always with APS, with HELLP (2/3 complete, 1/3 incomplete), and only in one‐third of the pregnancies with pre‐eclampsia (PE).